Industrial Equip Wash Inc

STERILIZATION IN PLACE (SIP) SYSTEMS:

Pharmaceutical Sterilization-in-Place (SIP) systems are designed to sterilize a collection of process equipment after a batch of product is completed. Equipment such as bioreactors, fermentors and the accompanying tubing must be cleaned and/or sterilized before a new production cycle .
The steam pressures seen are typically in the 20-30 psi range with corresponding temperatures ranging from 121ºC to 135ºC. The relationship between pressure and temperature is a given, however sterilization times will range depending on the temperature and the nature of the item being sterilized. In general, the lower the temperature, the longer it takes to sterilize. The sterilization time/temperature relationship in a typical SIP process will occur at about 121ºC for 30-40 minutes. For systems with hard to reach components, times can increase.
Steam quality is also an important consideration. Typically, a dedicated clean-steam generator is used to provide the necessary volume, temperature and pressure of steam needed to sterilize each system. To ensure that each component and all areas of the piping reach the sterilization temperature for the requisite time, temperature sensors are placed in critical areas as well as in hard-to-reach locations to ensure that complete sterilization occurs. During this entire process, modulating valves are utilized to maintain the required clean steam pressure, temperature and flow levels.
During the SIP process, condensate is generated from steam which must be quickly removed. Proper placement of clean steam traps will ensure timely and adequate removal of the condensate, which, in turn, will help to maintain the high temperatures needed for the sterilization cycle.
Besides the critical function of the clean steam generator, three components in particular are crucial to maintaining adequate wet temperature in SIP networks: sanitary control valves, sanitary pressure regulators and sanitary steam traps.
SYSTEM DETAILS 
The SIP has a microprocessor control system for temperature monitoring throughout the sterilisation cycle with validation printout facility 

About Us:

Industrial EquipWash Inc. are India^,s leading manufacturers of sanitary stainless steel piping, cleaning & sanitising equipment,customised aseptic proceess equipment & clean room acessories for the pharma, bio-pharma, food, beverage, cosmetics ,breweries, dairy & allied industries.
IEWI was established in 2001 by a team of experienced engineers with a mission to provide reliable,cost-effective aseptic process equipment conforming to FDA and cGMP standards.Our equipment have been meeting the needs of our customers all over India and also exported to European Union, UAE, Malaysia,Hong Kong, Bangladesh, Kenya, & others. We have a committed team of engineers, tecnicians & application specialists to deliver demanding aseptic process equipment. 

Manufacturing Infrastructure
IEWI have modern facillities for engineering design, manufacture & testing whether euipment meet user requirement specifications .We have a team of technicians for on-site errection and after sales service.

Validation Support

Our equipment conform to FDA/ cGMP standards ,we provide validation documentation (DQ,IQ,OQ & PQ) and SOPs for regulatory approvals.